Fragment screening for a protein-protein interaction inhibitor to WDR5

The WD40-repeat protein WDR5 scaffolds various epigenetic writers and is a critical component of the mammalian SET/MLL histone methyltransferase complex. Dysregulation of the MLL1 catalytic function is associated with mixed-lineage leukemia, and antagonism of the WDR5-MLL1 interaction by small molec...

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Detalles Bibliográficos
Autores principales: Dennis, Matthew L., Morrow, Benjamin J., Dolezal, Olan, Cuzzupe, Anthony N., Stupple, Alexandra E., Newman, Janet, Bentley, John, Hattarki, Meghan, Nuttall, Stewart D., Foitzik, Richard C., Street, Ian P., Stupple, Paul A., Monahan, Brendon J., Peat, Thomas. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Crystallographic Association 2019
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859963/
https://www.ncbi.nlm.nih.gov/pubmed/31768400
http://dx.doi.org/10.1063/1.5122849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859963/
https://www.ncbi.nlm.nih.gov/pubmed/31768400
http://dx.doi.org/10.1063/1.5122849

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