Cargando…

Fragment screening for a protein-protein interaction inhibitor to WDR5

The WD40-repeat protein WDR5 scaffolds various epigenetic writers and is a critical component of the mammalian SET/MLL histone methyltransferase complex. Dysregulation of the MLL1 catalytic function is associated with mixed-lineage leukemia, and antagonism of the WDR5-MLL1 interaction by small molec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dennis, Matthew L., Morrow, Benjamin J., Dolezal, Olan, Cuzzupe, Anthony N., Stupple, Alexandra E., Newman, Janet, Bentley, John, Hattarki, Meghan, Nuttall, Stewart D., Foitzik, Richard C., Street, Ian P., Stupple, Paul A., Monahan, Brendon J., Peat, Thomas. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Crystallographic Association 2019
Materias:	ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859963/ https://www.ncbi.nlm.nih.gov/pubmed/31768400 http://dx.doi.org/10.1063/1.5122849

Ejemplares similares

Crystal structures of human ENPP1 in apo and bound forms
por: Dennis, Matthew L., et al.
Publicado: (2020)

Exploring the Chemical Space around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme HPPK
por: Chhabra, Sandeep, et al.
Publicado: (2013)

The DINGO dataset: a comprehensive set of data for the SAMPL challenge
por: Newman, Janet, et al.
Publicado: (2011)

The intersection between Descriptivism and Meliorism in reasoning research: further proposals in support of ‘soft normativism’
por: Stupple, Edward J. N., et al.
Publicado: (2014)

Author Correction: The reproducibility crisis in the age of digital medicine
por: Stupple, Aaron, et al.
Publicado: (2019)

The reproducibility crisis in the age of digital medicine
por: Stupple, Aaron, et al.
Publicado: (2019)

Sweating the small stuff: A meta-analysis of skin conductance on the Iowa gambling task
por: Simonovic, Boban, et al.
Publicado: (2019)

Using Eye Tracking to Explore Facebook Use and Associations with Facebook Addiction, Mental Well-being, and Personality
por: Hussain, Zaheer, et al.
Publicado: (2019)

Performance Under Stress: An Eye-Tracking Investigation of the Iowa Gambling Task (IGT)
por: Simonovic, Boban, et al.
Publicado: (2018)

The impact of pop-up warning messages of losses on expenditure in a simulated game of online roulette: a pilot study
por: McGivern, Paul, et al.
Publicado: (2019)

A Systematic Review of Self-Report Measures of Negative Self-Referential Emotions Developed for Non-Clinical Child and Adolescent Samples
por: Ashra, Hajra, et al.
Publicado: (2021)

The role of WDR76 protein in human diseases
por: Yang, Jie, et al.
Publicado: (2021)

Editorial: The Marketization of Higher Education: The State of the Union Between the Student as Consumer and the Free Market
por: Howard, Chris, et al.
Publicado: (2022)

Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins
por: Caputo, Alessandro T., et al.
Publicado: (2021)

Docking interactions of the JNK scaffold protein WDR62
por: Cohen-Katsenelson, Ksenya, et al.
Publicado: (2011)

Factor and reliability analysis of a brief scale to measure motivation to change lifestyle for dementia risk reduction in the UK: the MOCHAD-10
por: Oliveira, Deborah, et al.
Publicado: (2019)

Exploring the Experience of Novelty When Viewing Creative Adverts: An ERP Study
por: Zhou, Shujin, et al.
Publicado: (2018)

Exploring pattern recognition: what is the relationship between the recognition of words, faces and other objects?
por: Maratos, F. A., et al.
Publicado: (2022)

Structure of S. aureus HPPK and the Discovery of a New Substrate Site Inhibitor
por: Chhabra, Sandeep, et al.
Publicado: (2012)

Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
por: Peat, Thomas S., et al.
Publicado: (2012)

Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
por: Peat, Thomas S., et al.
Publicado: (2013)

Slower is not always better: Response-time evidence clarifies the limited role of miserly information processing in the Cognitive Reflection Test
por: Stupple, Edward J. N., et al.
Publicado: (2017)

Exploring the Reliability and Validity of the Huntington’s Disease Quality of Life Battery for Carers (HDQoL-C) within A Polish Population
por: Bartoszek, Agnieszka, et al.
Publicado: (2019)

The evolving story of AtzT, a periplasmic binding protein
por: Dennis, Matthew L., et al.
Publicado: (2019)

Standardised colour-coded compartmentalised syringe trays improve anaesthetic medication visual search and mitigate cognitive load()
por: Laxton, Victoria, et al.
Publicado: (2023)

5S solutions to promote medication efficiency and safety. Comment on Br J Anaesth 2023; 130: e416–8
por: Laxton, Victoria, et al.
Publicado: (2023)

Data science to analyse the largest natural experiment of our time
por: Dee, Edward Christopher, et al.
Publicado: (2020)

WDR5 is a conserved regulator of protein synthesis gene expression
por: Bryan, Audra F, et al.
Publicado: (2020)

The Monty Hall problem revisited: Autonomic arousal in an inverted version of the game
por: Massad, Eduardo, et al.
Publicado: (2018)

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage
por: Gilmore, Joshua M., et al.
Publicado: (2016)

Structural insights into the activation of USP46 by WDR48 and WDR20
por: Zhu, Hanwen, et al.
Publicado: (2019)

Evolutionary comparison of competitive protein-complex formation of MYB, bHLH, and WDR proteins in plants
por: Zhang, Bipei, et al.
Publicado: (2019)

The Arabidopsis DDB1 interacting protein WDR55 is required for vegetative development
por: Bjerkan, Katrine N, et al.
Publicado: (2013)

Beta-Propeller-Protein-Associated Neurodegeneration: A Case of Mutation in WDR45
por: Ryu, Sook Won, et al.
Publicado: (2015)

The Spindle-Associated Microcephaly Protein, WDR62, Is Required for Neurogenesis and Development of the Hippocampus
por: Shohayeb, Belal, et al.
Publicado: (2020)

The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein
por: Newman, Janet, et al.
Publicado: (2020)

Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11
por: Thibodeau, Matthew C., et al.
Publicado: (2022)

WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis: WDR38 interacts with RAB19 and GM130 in acrosome biogenesis
por: Gao, Qiujie, et al.
Publicado: (2023)

WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity
por: Steib, Emmanuelle, et al.
Publicado: (2020)

A Genetic Screen Identifies a Critical Role for the WDR81‐WDR91 Complex in the Trafficking and Degradation of Tetherin
por: Rapiteanu, Radu, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jc2u74io4cir5vd97rcjasd713