Biallelic mutations in CFAP65 lead to severe asthenoteratospermia due to acrosome hypoplasia and flagellum malformations

BACKGROUND: The genetic causes for most male infertility due to severe asthenozoospermia remain unclear. OBJECTIVE: Our objective was to identify unknown genetic factors in 47 patients with severe asthenozoospermia from 45 unrelated Chinese families. METHODS: We performed whole exome sequencing of 4...

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Detalles Bibliográficos
Autores principales: Wang, Weili, Tu, Chaofeng, Nie, Hongchuan, Meng, Lanlan, Li, Yong, Yuan, Shimin, Zhang, Qianjun, Du, Juan, Wang, Junpu, Gong, Fei, Fan, Liqing, Lu, Guang-Xiu, Lin, Ge, Tan, Yue-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Gametes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860412/
https://www.ncbi.nlm.nih.gov/pubmed/31413122
http://dx.doi.org/10.1136/jmedgenet-2019-106031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860412/
https://www.ncbi.nlm.nih.gov/pubmed/31413122
http://dx.doi.org/10.1136/jmedgenet-2019-106031

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