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Biallelic mutations in CFAP65 lead to severe asthenoteratospermia due to acrosome hypoplasia and flagellum malformations

BACKGROUND: The genetic causes for most male infertility due to severe asthenozoospermia remain unclear. OBJECTIVE: Our objective was to identify unknown genetic factors in 47 patients with severe asthenozoospermia from 45 unrelated Chinese families. METHODS: We performed whole exome sequencing of 4...

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Detalles Bibliográficos
Autores principales:	Wang, Weili, Tu, Chaofeng, Nie, Hongchuan, Meng, Lanlan, Li, Yong, Yuan, Shimin, Zhang, Qianjun, Du, Juan, Wang, Junpu, Gong, Fei, Fan, Liqing, Lu, Guang-Xiu, Lin, Ge, Tan, Yue-Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Gametes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860412/ https://www.ncbi.nlm.nih.gov/pubmed/31413122 http://dx.doi.org/10.1136/jmedgenet-2019-106031

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