Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

Adopting a systems approach, we devise a general workflow to define actionable subtypes in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four subtypes based on global gene expression patterns and ontologies. Three correspond to known subtypes (SCLC-A, SCLC-N, and S...

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Detalles Bibliográficos
Autores principales: Wooten, David J., Groves, Sarah M., Tyson, Darren R., Liu, Qi, Lim, Jing S., Albert, Réka, Lopez, Carlos F., Sage, Julien, Quaranta, Vito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860456/
https://www.ncbi.nlm.nih.gov/pubmed/31671086
http://dx.doi.org/10.1371/journal.pcbi.1007343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860456/
https://www.ncbi.nlm.nih.gov/pubmed/31671086
http://dx.doi.org/10.1371/journal.pcbi.1007343

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