Cargando…

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

Adopting a systems approach, we devise a general workflow to define actionable subtypes in human cancers. Applied to small cell lung cancer (SCLC), the workflow identifies four subtypes based on global gene expression patterns and ontologies. Three correspond to known subtypes (SCLC-A, SCLC-N, and S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wooten, David J., Groves, Sarah M., Tyson, Darren R., Liu, Qi, Lim, Jing S., Albert, Réka, Lopez, Carlos F., Sage, Julien, Quaranta, Vito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860456/ https://www.ncbi.nlm.nih.gov/pubmed/31671086 http://dx.doi.org/10.1371/journal.pcbi.1007343

Ejemplares similares

Involvement of Epithelial–Mesenchymal Transition Genes in Small Cell Lung Cancer Phenotypic Plasticity
por: Groves, Sarah M., et al.
Publicado: (2023)

Thunor: visualization and analysis of high-throughput dose–response datasets
por: Lubbock, Alexander L R, et al.
Publicado: (2021)

Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype
por: Wu, Yonghe, et al.
Publicado: (2020)

Unified tumor growth mechanisms from multimodel inference and dataset integration
por: Beik, Samantha P., et al.
Publicado: (2023)

MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery
por: Wooten, David J., et al.
Publicado: (2021)

Fractional Proliferation: A method to deconvolve cell population dynamics from single-cell data
por: Tyson, Darren R., et al.
Publicado: (2012)

Quantifying cancer cell plasticity with gene regulatory networks and single-cell dynamics
por: Groves, Sarah M., et al.
Publicado: (2023)

Master Regulators, Regulatory Networks, and Pathways of Glioblastoma Subtypes
por: Bozdag, Serdar, et al.
Publicado: (2014)

Purinergic calcium signaling drives drug tolerance through ERK reactivation in BRAF-mutant melanoma
por: Stauffer, Philip E., et al.
Publicado: (2023)

Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation
por: Sivakumar, Smruthy, et al.
Publicado: (2023)

A drift-diffusion checkpoint model predicts a highly variable and growth-factor-sensitive portion of the cell cycle G1 phase
por: Jones, Zack W., et al.
Publicado: (2018)

Correction to “Master Regulators, Regulatory Networks, and Pathways of Glioblastoma Subtypes”
por: Bozdag, Serdar, et al.
Publicado: (2014)

Real-time luminescence enables continuous drug–response analysis in adherent and suspension cell lines
por: Wandishin, Clayton M., et al.
Publicado: (2022)

Small Molecule Inhibition of SAMHD1 dNTPase by Tetramer Destabilization
por: Seamon, Kyle J., et al.
Publicado: (2014)

A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein
por: Carver, Joseph, et al.
Publicado: (2014)

Protocol for Designing Small-Molecule-Regulated Destabilizing Domains for In Vitro Use
por: Ramadurgum, Prerana, et al.
Publicado: (2020)

The Destabilization of Domestic Psychiatry
por: EIGEN, JOEL
Publicado: (2007)

A Mutation Identified in Neonatal Microcephaly Destabilizes Zika Virus NS1 Assembly in Vitro
por: Wang, Deping, et al.
Publicado: (2017)

Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma
por: Janky, Rekin’s, et al.
Publicado: (2016)

An unbiased metric of antiproliferative drug effect in vitro
por: Harris, Leonard A., et al.
Publicado: (2016)

Clinically-identified C-terminal mutations in fibulin-3 are prone to misfolding and destabilization
por: Woodard, DaNae R., et al.
Publicado: (2021)

Destabilization of the Bacterial Interactome Identifies Nutrient Restriction-Induced Dysbiosis in Insect Guts
por: Marasco, Ramona, et al.
Publicado: (2022)

Mechanisms of small cell lung cancer metastasis
por: Ko, Julie, et al.
Publicado: (2020)

Data-Driven Math Model of FLT3-ITD Acute Myeloid Leukemia Reveals Potential Therapeutic Targets
por: Wooten, David J., et al.
Publicado: (2021)

On the plasticity of amyloid formation: The impact of destabilizing small to large substitutions on islet amyloid polypeptide amyloid formation
por: Manathunga, Lakshan, et al.
Publicado: (2023)

Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo
por: Peng, Hui, et al.
Publicado: (2019)

Transcriptional selectors, masters, and combinatorial codes: regulatory principles of neural subtype specification
por: Allan, Douglas W, et al.
Publicado: (2015)

Integrative multi-omics networks identify PKCδ and DNA-PK as master kinases of glioblastoma subtypes and guide targeted cancer therapy
por: Migliozzi, Simona, et al.
Publicado: (2023)

Metacommentary: Identifying and Mastering ‘Dear Reader’ Moments
por: Lingard, Lorelei
Publicado: (2023)

Emulsion Destabilization by Squeeze Flow
por: Dekker, Riande I., et al.
Publicado: (2020)

Identifying Endogenous Cellular Proteins Destabilizing the Propagation of Swi1 Prion upon Overproduction
por: Du, Zhiqiang, et al.
Publicado: (2022)

An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability
por: Hayford, Corey E., et al.
Publicado: (2021)

Selective destabilization of polypeptides synthesized from NMD-targeted transcripts
por: Chu, Vincent, et al.
Publicado: (2021)

Taking it up a notch: a promising immunotherapy against small cell lung cancer
por: Apaydin, Alanisse A., et al.
Publicado: (2023)

Antitumor Effect of Calcium-Mediated Destabilization of Epithelial Growth Factor Receptor on Non-Small Cell Lung Carcinoma
por: Kim, In Un, et al.
Publicado: (2018)

Newly identified aspects of tumor suppression by RB
por: Viatour, Patrick, et al.
Publicado: (2011)

Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes
por: Davidson, Kathryn, et al.
Publicado: (2021)

Age- and Sex-Differences in Cardiac Characteristics Determined by Echocardiography in Masters Athletes
por: Wooten, Savannah V., et al.
Publicado: (2021)

DLL3 regulates Notch signaling in small cell lung cancer
por: Kim, Jun W., et al.
Publicado: (2022)

Stroma-associated master regulators of molecular subtypes predict patient prognosis in ovarian cancer
por: Zhang, Shengzhe, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_tnhs68eh4k1f453vllqft9brio