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Chemogenetic Activation of Excitatory Neurons Alters Hippocampal Neurotransmission in a Dose-Dependent Manner

Designer receptors exclusively activated by designer drugs (DREADD)-based chemogenetic tools are extensively used to manipulate neuronal activity in a cell type-specific manner. Whole-cell patch-clamp recordings indicate membrane depolarization, coupled with increased neuronal firing rate, following...

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Detalles Bibliográficos
Autores principales: Pati, Sthitapranjya, Salvi, Sonali S., Kallianpur, Mamata, Vaidya, Bhupesh, Banerjee, Antara, Maiti, Sudipta, Clement, James P., Vaidya, Vidita A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860986/
https://www.ncbi.nlm.nih.gov/pubmed/31645362
http://dx.doi.org/10.1523/ENEURO.0124-19.2019