Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

RNA polymerase III (Pol-III) transcribes tRNAs and other small RNAs essential for protein synthesis and cell growth. Pol-III is deregulated during carcinogenesis; however, its role in vivo has not been studied. To address this issue, we manipulated levels of Brf1, a Pol-III transcription factor that...

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Detalles Bibliográficos
Autores principales: Liko, Dritan, Mitchell, Louise, Campbell, Kirsteen J., Ridgway, Rachel A., Jones, Carolyn, Dudek, Kate, King, Ayala, Bryson, Sheila, Stevenson, David, Blyth, Karen, Strathdee, Douglas, Morton, Jennifer P., Bird, Thomas G., Knight, John R. P., Willis, Anne E., Sansom, Owen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861133/
https://www.ncbi.nlm.nih.gov/pubmed/30858608
http://dx.doi.org/10.1038/s41418-019-0316-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861133/
https://www.ncbi.nlm.nih.gov/pubmed/30858608
http://dx.doi.org/10.1038/s41418-019-0316-7

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