Computational Insight Into the Small Molecule Intervening PD-L1 Dimerization and the Potential Structure-Activity Relationship

Recently, small-molecule compounds have been reported to block the PD-1/PD-L1 interaction by inducing the dimerization of PD-L1. All these inhibitors had a common scaffold and interacted with the cavity formed by two PD-L1 monomers. This special interactive mode provided clues for the structure-base...

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Detalles Bibliográficos
Autores principales: Shi, Danfeng, An, Xiaoli, Bai, Qifeng, Bing, Zhitong, Zhou, Shuangyan, Liu, Huanxiang, Yao, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861162/
https://www.ncbi.nlm.nih.gov/pubmed/31781546
http://dx.doi.org/10.3389/fchem.2019.00764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861162/
https://www.ncbi.nlm.nih.gov/pubmed/31781546
http://dx.doi.org/10.3389/fchem.2019.00764

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