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JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation

Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from hematopoietic stem cells (HSCs) that differentiate through common lymphoid progenitors (CLPs) to NK lineage-restri...

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Autores principales: Gotthardt, Dagmar, Trifinopoulos, Jana, Sexl, Veronika, Putz, Eva Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861185/
https://www.ncbi.nlm.nih.gov/pubmed/31781102
http://dx.doi.org/10.3389/fimmu.2019.02590
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author Gotthardt, Dagmar
Trifinopoulos, Jana
Sexl, Veronika
Putz, Eva Maria
author_facet Gotthardt, Dagmar
Trifinopoulos, Jana
Sexl, Veronika
Putz, Eva Maria
author_sort Gotthardt, Dagmar
collection PubMed
description Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from hematopoietic stem cells (HSCs) that differentiate through common lymphoid progenitors (CLPs) to NK lineage-restricted progenitors (NKPs). The orchestrated action of multiple cytokines is crucial for NK cell development and maturation. Many of these cytokines such as IL-2, IL-7, IL-12, IL-15, IL-21, IL-27, and interferons (IFNs) signal via the Janus Kinase / Signal Transducer and Activator of Transcription (JAK/STAT) pathway. We here review the current knowledge about these cytokines and the downstream signaling involved in the development and maturation of conventional NK cells and their close relatives, innate lymphoid cells type 1 (ILC1). We further discuss the role of suppressor of cytokine signaling (SOCS) proteins in NK cells and highlight their potential for therapeutic application.
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spelling pubmed-68611852019-11-28 JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation Gotthardt, Dagmar Trifinopoulos, Jana Sexl, Veronika Putz, Eva Maria Front Immunol Immunology Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from hematopoietic stem cells (HSCs) that differentiate through common lymphoid progenitors (CLPs) to NK lineage-restricted progenitors (NKPs). The orchestrated action of multiple cytokines is crucial for NK cell development and maturation. Many of these cytokines such as IL-2, IL-7, IL-12, IL-15, IL-21, IL-27, and interferons (IFNs) signal via the Janus Kinase / Signal Transducer and Activator of Transcription (JAK/STAT) pathway. We here review the current knowledge about these cytokines and the downstream signaling involved in the development and maturation of conventional NK cells and their close relatives, innate lymphoid cells type 1 (ILC1). We further discuss the role of suppressor of cytokine signaling (SOCS) proteins in NK cells and highlight their potential for therapeutic application. Frontiers Media S.A. 2019-11-12 /pmc/articles/PMC6861185/ /pubmed/31781102 http://dx.doi.org/10.3389/fimmu.2019.02590 Text en Copyright © 2019 Gotthardt, Trifinopoulos, Sexl and Putz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gotthardt, Dagmar
Trifinopoulos, Jana
Sexl, Veronika
Putz, Eva Maria
JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
title JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
title_full JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
title_fullStr JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
title_full_unstemmed JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
title_short JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
title_sort jak/stat cytokine signaling at the crossroad of nk cell development and maturation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861185/
https://www.ncbi.nlm.nih.gov/pubmed/31781102
http://dx.doi.org/10.3389/fimmu.2019.02590
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