Cargando…
Functional tunability from a distance: Rheostat positions influence allosteric coupling between two distant binding sites
For protein mutagenesis, a common expectation is that important positions will behave like on/off “toggle” switches (i.e., a few substitutions act like wildtype, most abolish function). However, there exists another class of important positions that manifests a wide range of functional outcomes upon...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861286/ https://www.ncbi.nlm.nih.gov/pubmed/31740686 http://dx.doi.org/10.1038/s41598-019-53464-z |