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Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells
Insulin signaling governs many processes including glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes. We demonstrated that insulin-induced Akt activation enhances the sensitivity to TGF-β by directing an increase in cell surface TGF-β receptors from a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861289/ https://www.ncbi.nlm.nih.gov/pubmed/31740700 http://dx.doi.org/10.1038/s41598-019-53490-x |