Molecular docking study of lamellarin analogues and identification of potential inhibitors of HIV-1 integrase strand transfer complex by virtual screening

Molecular docking has been applied to elucidate the binding of lamellarin analogues with HIV-1 integrase strand transfer complex (PDB ID: 5U1C). The results suggest hydrogen bond interaction with residue Glu92 is key, and stabilisation by π−π stacking interactions with DNA base is chiefly influentia...

Descripción completa

Detalles Bibliográficos
Autores principales: Eurtivong, Chatchakorn, Choowongkomon, Kiattawee, Ploypradith, Poonsakdi, Ruchirawat, Somsak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861579/
https://www.ncbi.nlm.nih.gov/pubmed/31763475
http://dx.doi.org/10.1016/j.heliyon.2019.e02811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861579/
https://www.ncbi.nlm.nih.gov/pubmed/31763475
http://dx.doi.org/10.1016/j.heliyon.2019.e02811

Ejemplares similares