Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition

Mitofusins are dynamin-related GTPases that drive mitochondrial fusion by sequential events of oligomerization and GTP hydrolysis, followed by their ubiquitylation. Here, we show that fusion requires a trilateral salt bridge at a hinge point of the yeast mitofusin Fzo1, alternatingly forming before...

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Detalles Bibliográficos
Autores principales: Anton, Vincent, Buntenbroich, Ira, Schuster, Ramona, Babatz, Felix, Simões, Tânia, Altin, Selver, Calabrese, Gaetano, Riemer, Jan, Schauss, Astrid, Escobar-Henriques, Mafalda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861704/
https://www.ncbi.nlm.nih.gov/pubmed/31740565
http://dx.doi.org/10.26508/lsa.201900491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861704/
https://www.ncbi.nlm.nih.gov/pubmed/31740565
http://dx.doi.org/10.26508/lsa.201900491

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