ZnT8 Haploinsufficiency Impacts MIN6 Cell Zinc Content and β-Cell Phenotype via ZIP-ZnT8 Coregulation

The zinc transporter ZnT8 (SLC30A8) localises to insulin secretory granules of β-cells where it facilitates zinc uptake for insulin crystallisation. ZnT8 abundance has been linked to β-cell survival and functional phenotype. However, the consequences of ZnT8 haploinsufficiency for β-cell zinc traffi...

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Detalles Bibliográficos
Autores principales: Lawson, Rebecca, Maret, Wolfgang, Hogstrand, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861948/
https://www.ncbi.nlm.nih.gov/pubmed/31690008
http://dx.doi.org/10.3390/ijms20215485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861948/
https://www.ncbi.nlm.nih.gov/pubmed/31690008
http://dx.doi.org/10.3390/ijms20215485

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