Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study

Based on the up-regulation of the proviral integration site of the Moloney murine leukemia virus (Pim) kinase family (Pim1, 2, and 3) observed in several types of leukemias and lymphomas, the development of pan-Pim inhibitors is an attractive therapeutic strategy. While only PIM447 and AZD1208 have...

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Detalles Bibliográficos
Autores principales: Chen, Qingqing, Wang, Yan, Shi, Shanshan, Li, Kaihang, Zhang, Ling, Gao, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862308/
https://www.ncbi.nlm.nih.gov/pubmed/31671637
http://dx.doi.org/10.3390/ijms20215410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862308/
https://www.ncbi.nlm.nih.gov/pubmed/31671637
http://dx.doi.org/10.3390/ijms20215410

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