Substitution of Arginine 120 in Human D-Amino Acid Oxidase Favors FAD-Binding and Nuclear Mistargeting

The peroxisomal enzyme human D-amino acid oxidase (hDAAO) is attracting attention owing to its role in degrading D-serine, the main co-agonist of N-methyl D-aspartate receptors in brain, and its involvement in brain functions and diseases. Here, we focused on arginine 120, a residue located at the p...

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Detalles Bibliográficos
Autores principales: Murtas, Giulia, Sacchi, Silvia, Pollegioni, Loredano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862323/
https://www.ncbi.nlm.nih.gov/pubmed/31799256
http://dx.doi.org/10.3389/fmolb.2019.00125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862323/
https://www.ncbi.nlm.nih.gov/pubmed/31799256
http://dx.doi.org/10.3389/fmolb.2019.00125

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