microRNA-mediated GAS1 downregulation promotes the proliferation of synovial fibroblasts by PI3K-Akt signaling in osteoarthritis

Hyperplastic synovial fibroblasts (SFs) serve a critical role in the pathogenesis of knee osteoarthritis (OA); however, the molecular mechanism involved in OA during synovial tissue hyperproliferation remains unclear. Growth arrest-specific gene 1 (GAS1), a cell growth repressor gene, was found to b...

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Detalles Bibliográficos
Autores principales: Dong, Chuan, Wang, Xinli, Li, Nan, Zhang, Kailiang, Wang, Xiaoyan, Zhang, Haomeng, Wang, Haipeng, Wang, Bo, An, Ming, Ma, Baoan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862556/
https://www.ncbi.nlm.nih.gov/pubmed/31777535
http://dx.doi.org/10.3892/etm.2019.8101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862556/
https://www.ncbi.nlm.nih.gov/pubmed/31777535
http://dx.doi.org/10.3892/etm.2019.8101

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