Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing

Spinocerebellar ataxia type 3 (SCA3) is a devastating neurodegenerative disease for which there is currently no cure, nor effective treatment strategy. One of nine polyglutamine disorders known to date, SCA3 is clinically heterogeneous and the main feature is progressive ataxia, which in turn affect...

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Detalles Bibliográficos
Autores principales: McIntosh, Craig S., Aung-Htut, May Thandar, Fletcher, Sue, Wilton, Steve D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862616/
https://www.ncbi.nlm.nih.gov/pubmed/31683630
http://dx.doi.org/10.3390/ijms20215434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862616/
https://www.ncbi.nlm.nih.gov/pubmed/31683630
http://dx.doi.org/10.3390/ijms20215434

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