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Understanding G Protein Selectivity of Muscarinic Acetylcholine Receptors Using Computational Methods

The neurotransmitter molecule acetylcholine is capable of activating five muscarinic acetylcholine receptors, M1 through M5, which belong to the superfamily of G-protein-coupled receptors (GPCRs). These five receptors share high sequence and structure homology; however, the M1, M3, and M5 receptor s...

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Detalles Bibliográficos
Autores principales: Santiago, Luis Jaimes, Abrol, Ravinder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862617/
https://www.ncbi.nlm.nih.gov/pubmed/31653051
http://dx.doi.org/10.3390/ijms20215290