SAR-mediated Similarity Assessment of the Property Profile for New, Silicon-Based AChE/BChE Inhibitors

A set of 25 novel, silicon-based carbamate derivatives as potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors was synthesized and characterized by their in vitro inhibition profiles and the selectivity indexes (SIs). The prepared compounds were also tested for their inhibition potenti...

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Detalles Bibliográficos
Autores principales: Bak, Andrzej, Pizova, Hana, Kozik, Violetta, Vorcakova, Katarina, Kos, Jiri, Treml, Jakub, Odehnalova, Klara, Oravec, Michal, Imramovsky, Ales, Bobal, Pavel, Smolinski, Adam, Trávníček, Zdeněk, Jampilek, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862691/
https://www.ncbi.nlm.nih.gov/pubmed/31671776
http://dx.doi.org/10.3390/ijms20215385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862691/
https://www.ncbi.nlm.nih.gov/pubmed/31671776
http://dx.doi.org/10.3390/ijms20215385

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