Concurrent genome and epigenome editing by CRISPR-mediated sequence replacement

BACKGROUND: Recent advances in genome editing have facilitated the direct manipulation of not only the genome, but also the epigenome. Genome editing is typically performed by introducing a single CRISPR/Cas9-mediated double-strand break (DSB), followed by non-homologous end joining (NHEJ)- or homol...

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Detalles Bibliográficos
Autores principales: Alexander, Jes, Findlay, Gregory M., Kircher, Martin, Shendure, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862751/
https://www.ncbi.nlm.nih.gov/pubmed/31739790
http://dx.doi.org/10.1186/s12915-019-0711-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862751/
https://www.ncbi.nlm.nih.gov/pubmed/31739790
http://dx.doi.org/10.1186/s12915-019-0711-z

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