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The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells
BACKGROUND: Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1(+)/MAGE-A4(−)), which fail to differentiate to pre-spermatogonia (POU5F1(−)/MAGE-A4(+)) and undergo malignant transformation. Gankyrin is an...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862764/ https://www.ncbi.nlm.nih.gov/pubmed/31744479 http://dx.doi.org/10.1186/s12885-019-6340-7 |