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Genetic dynamics in untreated CLL patients with either stable or progressive disease: a longitudinal study

Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive dis...

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Detalles Bibliográficos
Autores principales: Ramassone, Alice, D’Argenio, Andrea, Veronese, Angelo, Basti, Alessio, Soliman, Shimaa Hassan AbdelAziz, Volinia, Stefano, Bassi, Cristian, Pagotto, Sara, Ferracin, Manuela, Lupini, Laura, Saccenti, Elena, Balatti, Veronica, Pepe, Felice, Rassenti, Laura Z., Innocenti, Idanna, Autore, Francesco, Marzetti, Laura, Mariani-Costantini, Renato, Kipps, Thomas J., Negrini, Massimo, Laurenti, Luca, Visone, Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862808/
https://www.ncbi.nlm.nih.gov/pubmed/31744508
http://dx.doi.org/10.1186/s13045-019-0802-x
Descripción
Sumario:Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.