Cargando…

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells (OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS). Consequently, regenerative approaches have significant potential for treating chronic demyelinating diseases. Here, we show t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Neumann, Björn, Baror, Roey, Zhao, Chao, Segel, Michael, Dietmann, Sabine, Rawji, Khalil S., Foerster, Sarah, McClain, Crystal R., Chalut, Kevin, van Wijngaarden, Peter, Franklin, Robin J.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863391/ https://www.ncbi.nlm.nih.gov/pubmed/31585093 http://dx.doi.org/10.1016/j.stem.2019.08.015

Ejemplares similares

Remyelination and ageing: Reversing the ravages of time
por: Neumann, Bjoern, et al.
Publicado: (2019)

Transforming growth factor‐beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors
por: Baror, Roey, et al.
Publicado: (2019)

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system
por: Rawji, Khalil S., et al.
Publicado: (2020)

Regenerative Capacity of Macrophages for Remyelination
por: Rawji, Khalil S., et al.
Publicado: (2016)

Correction to: Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system
por: Rawji, Khalil S., et al.
Publicado: (2020)

CNS Remyelination and the Innate Immune System
por: McMurran, Christopher E., et al.
Publicado: (2016)

What roles do growth factors play in CNS remyelination?
por: Franklin, Robin J.M., et al.
Publicado: (2001)

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination
por: De La Fuente, Alerie Guzman, et al.
Publicado: (2017)

Hedgehog Signaling in CNS Remyelination
por: Fang, Minxi, et al.
Publicado: (2022)

Motor Learning Promotes Remyelination via New and Surviving Oligodendrocytes
por: Bacmeister, Clara M., et al.
Publicado: (2020)

Astrocyte Regulation of CNS Inflammation and Remyelination
por: Claycomb, Kumiko I., et al.
Publicado: (2013)

Central Nervous System Remyelination: Roles of Glia and Innate Immune Cells
por: Baaklini, Charbel S., et al.
Publicado: (2019)

The Current Challenges for Drug Discovery in CNS Remyelination
por: Balestri, Sonia, et al.
Publicado: (2021)

CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes
por: Dimas, Penelope, et al.
Publicado: (2019)

Utilizing mouse optic nerve crush to examine CNS remyelination
por: Suter, Tracey A.C.S., et al.
Publicado: (2021)

Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination
por: Syed, Yasir A., et al.
Publicado: (2015)

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation
por: Wong, Wai T.
Publicado: (2013)

Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination
por: Syed, Yasir A, et al.
Publicado: (2013)

Tracking the evolution of CNS remyelinating lesion in mice with neutral red dye
por: Baydyuk, Maryna, et al.
Publicado: (2019)

Prolonging the integrated stress response enhances CNS remyelination in an inflammatory environment
por: Chen, Yanan, et al.
Publicado: (2021)

Baicalin Promotes CNS Remyelination via PPARγ Signal Pathway
por: Ai, Ruo-Song, et al.
Publicado: (2022)

Nalfurafine reduces neuroinflammation and drives remyelination in models of CNS demyelinating disease
por: Denny, Lisa, et al.
Publicado: (2021)

Erratum to: Antibody-mediated neutralization of myelin-associated EphrinB3 accelerates CNS remyelination
por: Syed, Yasir A., et al.
Publicado: (2016)

Treatment of facial rejuvenation with fat restoration
por: Mousavi, Seyed Reza
Publicado: (2010)

Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned
por: Gudi, Viktoria, et al.
Publicado: (2014)

Chd7 Cooperates with Sox10 and Regulates the Onset of CNS Myelination and Remyelination
por: He, Danyang, et al.
Publicado: (2016)

The choline pathway as a strategy to promote central nervous system (CNS) remyelination
por: Skripuletz, Thomas, et al.
Publicado: (2015)

Emerging Cellular and Molecular Strategies for Enhancing Central Nervous System (CNS) Remyelination
por: Abu-Rub, Mohammad, et al.
Publicado: (2018)

Tuftsin Combines With Remyelinating Therapy and Improves Outcomes in Models of CNS Demyelinating Disease
por: Thompson, Kaitlyn K., et al.
Publicado: (2018)

Teriflunomide Promotes Oligodendroglial 8,9-Unsaturated Sterol Accumulation and CNS Remyelination
por: Martin, Elodie, et al.
Publicado: (2021)

Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination
por: Hou, Jinchao, et al.
Publicado: (2023)

Efficient Remyelination Requires DNA Methylation
por: Moyon, Sarah, et al.
Publicado: (2017)

The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination
por: McMurran, Christopher E., et al.
Publicado: (2019)

Contribution of Schwann Cells to Remyelination in a Naturally Occurring Canine Model of CNS Neuroinflammation
por: Kegler, Kristel, et al.
Publicado: (2015)

Rejuvenating regeneration: Metformin activates endogenous adult stem cells
por: Menendez, Javier A., et al.
Publicado: (2012)

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
por: Keough, Michael B., et al.
Publicado: (2016)

Rejuvenating stem cells to restore muscle regeneration in aging
por: Bengal, Eyal, et al.
Publicado: (2017)

Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination
por: de la Vega Gallardo, Nira, et al.
Publicado: (2020)

Csf1 Deficiency Dysregulates Glial Responses to Demyelination and Disturbs CNS White Matter Remyelination
por: Wylot, Bartosz, et al.
Publicado: (2019)

Schwann cell remyelination of the central nervous system: why does it happen and what are the benefits?
por: Chen, Civia Z., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pm86n0o22ghlump1fm971030nc