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Tandem domain swapping: determinants of multidomain protein misfolding

Tandem homologous domains in proteins are susceptible to misfolding through the formation of domain swaps, non-native conformations involving the exchange of equivalent structural elements between adjacent domains. Cutting-edge biophysical experiments have recently allowed the observation of tandem...

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Detalles Bibliográficos
Autores principales: Lafita, Aleix, Tian, Pengfei, Best, Robert B, Bateman, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863430/
https://www.ncbi.nlm.nih.gov/pubmed/31260947
http://dx.doi.org/10.1016/j.sbi.2019.05.012