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Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3
Although the process of autophagy has been extensively studied, the mechanisms that regulate it remain insufficiently understood. To identify novel autophagy regulators, we performed a whole-genome CRISPR/Cas9 knockout screen in H4 human neuroglioma cells expressing endogenous LC3B tagged with a tan...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863627/ https://www.ncbi.nlm.nih.gov/pubmed/31692446 http://dx.doi.org/10.7554/eLife.50034 |