Chaperone Sigma1R mediates the neuroprotective action of afobazole in the 6-OHDA model of Parkinson’s disease

Parkinson’s disease (PD) is a progressive neurodegenerative disease with limited treatment options. Therefore, the identification of therapeutic targets is urgently needed. Previous studies have shown that the ligand activation of the sigma-1 chaperone (Sigma1R) promotes neuroprotection. The multita...

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Detalles Bibliográficos
Autores principales: Voronin, Mikhail V., Kadnikov, Ilya A., Voronkov, Dmitry N., Seredenin, Sergey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863824/
https://www.ncbi.nlm.nih.gov/pubmed/31745133
http://dx.doi.org/10.1038/s41598-019-53413-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863824/
https://www.ncbi.nlm.nih.gov/pubmed/31745133
http://dx.doi.org/10.1038/s41598-019-53413-w

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