Inhibition of PTP1B blocks pancreatic cancer progression by targeting the PKM2/AMPK/mTOC1 pathway

Pancreatic cancer is a highly malignant cancer and lacks effective therapeutic targets. Protein-tyrosine phosphatase 1B (PTP1B), a validated therapeutic target for diabetes and obesity, also plays a critical positive or negative role in tumorigenesis. However, the role of PTP1B in pancreatic cancer...

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Detalles Bibliográficos
Autores principales: Xu, Qi, Wu, Ning, Li, Xiangqian, Guo, Chuanlong, Li, Chao, Jiang, Bo, Wang, Huaizhi, Shi, Dayong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864061/
https://www.ncbi.nlm.nih.gov/pubmed/31745071
http://dx.doi.org/10.1038/s41419-019-2073-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864061/
https://www.ncbi.nlm.nih.gov/pubmed/31745071
http://dx.doi.org/10.1038/s41419-019-2073-4

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