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Molecular basis for the interaction between human choline kinase alpha and the SH3 domain of the c-Src tyrosine kinase
Choline kinase alpha is a 457-residue protein that catalyzes the reaction between ATP and choline to yield ADP and phosphocholine. This metabolic action has been well studied because of choline kinase’s link to cancer malignancy and poor patient prognosis. As the myriad of x-ray crystal structures a...
Autores principales: | Kall, Stefanie L., Whitlatch, Kindra, Smithgall, Thomas E., Lavie, Arnon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864063/ https://www.ncbi.nlm.nih.gov/pubmed/31745227 http://dx.doi.org/10.1038/s41598-019-53447-0 |
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