Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation

PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytotoxicity of PARPi, however, is incompletely understood. Here we designed a series of small molecule PA...

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Detalles Bibliográficos
Autores principales: Wang, Shuai, Han, Lei, Han, Jungsoo, Li, Peng, Ding, Qing, Zhang, Qing-Jun, Liu, Zhi-Ping, Chen, Chuo, Yu, Yonghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864272/
https://www.ncbi.nlm.nih.gov/pubmed/31659317
http://dx.doi.org/10.1038/s41589-019-0379-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864272/
https://www.ncbi.nlm.nih.gov/pubmed/31659317
http://dx.doi.org/10.1038/s41589-019-0379-2

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