Cargando…

Novel C7-Substituted Coumarins as Selective Monoamine Oxidase Inhibitors: Discovery, Synthesis and Theoretical Simulation

There is a continued need to develop new selective human monoamine oxidase (hMAO) inhibitors that could be beneficial for the treatment of neurological diseases. However, hMAOs are closely related with high sequence identity and structural similarity, which hinders the development of selective MAO i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Dong, Hong, Ren-Yuan, Guo, Mengyao, Liu, Yi, Chen, Nianhang, Li, Xun, Kong, De-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864482/ https://www.ncbi.nlm.nih.gov/pubmed/31694262 http://dx.doi.org/10.3390/molecules24214003

Ejemplares similares

Halogenated Coumarin–Chalcones as Multifunctional Monoamine Oxidase-B and Butyrylcholinesterase Inhibitors
por: Rehuman, Nisha Abdul, et al.
Publicado: (2021)

Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures
por: Ekström, Fredrik, et al.
Publicado: (2022)

Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B
por: Kong, Zhuo, et al.
Publicado: (2020)

ABUSE OF MONOAMINE OXIDASE INHIBITORS
por: Ananth, Jambur, et al.
Publicado: (1995)

Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin versus trans-6-Styrylcoumarin
por: Mellado, Marco, et al.
Publicado: (2022)

Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors
por: Chiuccariello, Lina, et al.
Publicado: (2015)

Amphetamine Derivatives as Monoamine Oxidase Inhibitors
por: Reyes-Parada, Miguel, et al.
Publicado: (2020)

Neuroprotective Function of Rasagiline and Selegiline, Inhibitors of Type B Monoamine Oxidase, and Role of Monoamine Oxidases in Synucleinopathies
por: Naoi, Makoto, et al.
Publicado: (2022)

Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis
por: Jeong, Geum Seok, et al.
Publicado: (2020)

3-Coumaranone derivatives as inhibitors of monoamine oxidase
por: Van Dyk, Adriaan S, et al.
Publicado: (2015)

Conjugated Dienones from Differently Substituted Cinnamaldehyde as Highly Potent Monoamine Oxidase-B Inhibitors: Synthesis, Biochemistry, and Computational Chemistry
por: Mathew, Bijo, et al.
Publicado: (2022)

Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease
por: Yusufzai, Samina Khan, et al.
Publicado: (2018)

Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies
por: Agamennone, Mariangela, et al.
Publicado: (2022)

Design, Synthesis, and Evaluation of Monoamine Oxidase A Inhibitors–Indocyanine Dyes Conjugates as Targeted Antitumor Agents
por: Yang, Xiao-Guang, et al.
Publicado: (2019)

2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors
por: Legoabe, Lesetja J, et al.
Publicado: (2015)

“Ping-pong gaze” secondary to monoamine oxidase inhibitor overdose
por: Attaway, Amy, et al.
Publicado: (2016)

Parameters for Irreversible Inactivation of Monoamine Oxidase
por: Ramsay, Rona R., et al.
Publicado: (2020)

Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations
por: Sasidharan, Rani, et al.
Publicado: (2021)

Synthesis and Evaluation of Novel S-alkyl Phthalimide- and S-benzyl-oxadiazole-quinoline Hybrids as Inhibitors of Monoamine Oxidase and Acetylcholinesterase
por: Khan, Bilal Ahmad, et al.
Publicado: (2022)

Natural Products Screening for the Identification of Selective Monoamine Oxidase-B Inhibitors
por: Zarmouh, Najla O., et al.
Publicado: (2016)

A Peroxidase-linked Spectrophotometric Assay for the Detection of Monoamine Oxidase Inhibitors
por: Zhi, Kangkang, et al.
Publicado: (2016)

Monoamine oxidase A (MAO A) inhibitors decrease glioma progression
por: Kushal, Swati, et al.
Publicado: (2016)

The evaluation of 1-tetralone and 4-chromanone derivatives as inhibitors of monoamine oxidase
por: Cloete, Stephanus J., et al.
Publicado: (2020)

Effects of Natural Monoamine Oxidase Inhibitors on Anxiety-Like Behavior in Zebrafish
por: Jaka, Oihane, et al.
Publicado: (2021)

Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors
por: Jayan, Jayalakshmi, et al.
Publicado: (2023)

Microbial Metabolites of 3-n-butylphthalide as Monoamine Oxidase A Inhibitors
por: Gach, Joanna, et al.
Publicado: (2023)

Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents
por: Mzezewa, Sheunopa C., et al.
Publicado: (2021)

Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents
por: Kapp, Erika, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
por: Turan-Zitouni, Gülhan, et al.
Publicado: (2018)

Synthesis and Biological Evaluation of 2-Phenoxyacetamide Analogues, a Novel Class of Potent and Selective Monoamine Oxidase Inhibitors
por: Shen, Wei, et al.
Publicado: (2014)

Total Synthesis and Monoamine Oxidase Inhibitory Activities of (±)-Entonalactam A and Its Derivatives
por: Kamauchi, Hitoshi, et al.
Publicado: (2022)

Monoamine Oxidase and Dopamine β-Hydroxylase Inhibitors from the Fruits of Gardenia jasminoides
por: Kim, Ji Ho, et al.
Publicado: (2012)

Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors
por: Sairam, Kalapatapu V.V.M., et al.
Publicado: (2007)

Evaluation of the Isoflavone Genistein as Reversible Human Monoamine Oxidase-A and -B Inhibitor
por: Zarmouh, Najla O., et al.
Publicado: (2016)

Navigating into the Chemical Space of Monoamine Oxidase Inhibitors by Artificial Intelligence and Cheminformatics Approach
por: Kumar, Sunil, et al.
Publicado: (2021)

Role of Monoamine Oxidase Activity in Alzheimer’s Disease: An Insight into the Therapeutic Potential of Inhibitors
por: Behl, Tapan, et al.
Publicado: (2021)

Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson’s Disease: Past, Present, and Future
por: Tan, Yu-Yan, et al.
Publicado: (2022)

Exploration of the Detailed Structure–Activity Relationships of Isatin and Their Isomers As Monoamine Oxidase Inhibitors
por: Kumar, Sunil, et al.
Publicado: (2022)

Molecular Investigation of the Antitumor Effects of Monoamine Oxidase Inhibitors in Breast Cancer Cells
por: Alkhawaldeh, Aseel, et al.
Publicado: (2023)

Monoamine Oxidase B in Renal Cell Carcinoma
por: Hodorová, Ingrid, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vka7pa2ot6m6s4auoj6ucafl0p