Design and Synthesis of Novel Breast Cancer Therapeutic Drug Candidates Based upon the Hydrophobic Feedback Approach of Antiestrogens

Based upon hydrophobic feedback approaches, we designed and synthesized novel sulfur-containing ERα modulators (4 and 5) as breast cancer therapeutic drug candidates. The tetrahydrothiepine derivative 5a showed the highest binding affinity toward ERα because of its high hydrophobicity, and it acted...

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Detalles Bibliográficos
Autores principales: Ohta, Kiminori, Kaise, Asako, Taguchi, Fumi, Aoto, Sayaka, Ogawa, Takumi, Endo, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864722/
https://www.ncbi.nlm.nih.gov/pubmed/31683895
http://dx.doi.org/10.3390/molecules24213966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864722/
https://www.ncbi.nlm.nih.gov/pubmed/31683895
http://dx.doi.org/10.3390/molecules24213966

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