Observations on the Effects of Residualization and Dehalogenation on the Utility of N-Succinimidyl Ester Acylation Agents for Radioiodination of the Internalizing Antibody Trastuzumab

Trastuzumab is an antibody used for the treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancers. Since trastuzumab is an internalizing antibody, two factors could play an important role in achieving high uptake and prolonged retention of radioactivity in HER2-posit...

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Detalles Bibliográficos
Autores principales: Chitneni, Satish K., Koumarianou, Eftychia, Vaidyanathan, Ganesan, Zalutsky, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864793/
https://www.ncbi.nlm.nih.gov/pubmed/31671554
http://dx.doi.org/10.3390/molecules24213907

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864793/
https://www.ncbi.nlm.nih.gov/pubmed/31671554
http://dx.doi.org/10.3390/molecules24213907

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