Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η

A wide range of endogenous and exogenous alkylating agents attack DNA to generate various alkylation adducts. N7-methyl-2-deoxyguanosine (Fm7dG) is the most abundant alkylative DNA lesion. If not repaired, Fm7dG can undergo spontaneous depurination, imidazole ring-opening, or bypass by translesion s...

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Detalles Bibliográficos
Autores principales: Koag, Myong-Chul, Jung, Hunmin, Kou, Yi, Lee, Seongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864850/
https://www.ncbi.nlm.nih.gov/pubmed/31683505
http://dx.doi.org/10.3390/molecules24213928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864850/
https://www.ncbi.nlm.nih.gov/pubmed/31683505
http://dx.doi.org/10.3390/molecules24213928

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