Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening

Morphine, oxycodone, fentanyl, and other µ-opioid receptors (MOR) agonists have been used for decades in antinociceptive therapies. However, these drugs are associated with numerous side effects, such as euphoria, addiction, respiratory depression, and adverse gastrointestinal reactions, thus, circu...

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Detalles Bibliográficos
Autores principales: Poli, Giulio, Dimmito, Marilisa Pia, Mollica, Adriano, Zengin, Gokhan, Benyhe, Sandor, Zador, Ferenc, Stefanucci, Azzurra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865014/
https://www.ncbi.nlm.nih.gov/pubmed/31717871
http://dx.doi.org/10.3390/molecules24213872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865014/
https://www.ncbi.nlm.nih.gov/pubmed/31717871
http://dx.doi.org/10.3390/molecules24213872

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