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Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

BACKGROUND: It is widely accepted that mitochondria have a direct impact on neuronal function and survival. Oxidative stress caused by mitochondrial abnormalities play an important role in the pathophysiology of lipopolysaccharide (LPS)-induced memory impairment. Elamipretide (SS-31) is a novel mito...

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Detalles Bibliográficos
Autores principales: Zhao, Weixing, Xu, Zhipeng, Cao, Jiangbei, Fu, Qiang, Wu, Yishuang, Zhang, Xiaoying, Long, Yue, Zhang, Xuan, Yang, Yitian, Li, Yunfeng, Mi, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865061/
https://www.ncbi.nlm.nih.gov/pubmed/31747905
http://dx.doi.org/10.1186/s12974-019-1627-9