Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol

Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and rea...

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Autores principales: Takenaga, Naoko, Shoji, Toshitaka, Menjo, Takayuki, Hirai, Akiko, Ueda, Shohei, Kikushima, Kotaro, Hanasaki, Tomonori, Dohi, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865213/
https://www.ncbi.nlm.nih.gov/pubmed/31652675
http://dx.doi.org/10.3390/molecules24213812
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author Takenaga, Naoko
Shoji, Toshitaka
Menjo, Takayuki
Hirai, Akiko
Ueda, Shohei
Kikushima, Kotaro
Hanasaki, Tomonori
Dohi, Toshifumi
author_facet Takenaga, Naoko
Shoji, Toshitaka
Menjo, Takayuki
Hirai, Akiko
Ueda, Shohei
Kikushima, Kotaro
Hanasaki, Tomonori
Dohi, Toshifumi
author_sort Takenaga, Naoko
collection PubMed
description Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and reagents for the syntheses of aryl-substituted purine analogues.
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spelling pubmed-68652132019-12-09 Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol Takenaga, Naoko Shoji, Toshitaka Menjo, Takayuki Hirai, Akiko Ueda, Shohei Kikushima, Kotaro Hanasaki, Tomonori Dohi, Toshifumi Molecules Communication Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and reagents for the syntheses of aryl-substituted purine analogues. MDPI 2019-10-23 /pmc/articles/PMC6865213/ /pubmed/31652675 http://dx.doi.org/10.3390/molecules24213812 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Takenaga, Naoko
Shoji, Toshitaka
Menjo, Takayuki
Hirai, Akiko
Ueda, Shohei
Kikushima, Kotaro
Hanasaki, Tomonori
Dohi, Toshifumi
Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol
title Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol
title_full Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol
title_fullStr Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol
title_full_unstemmed Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol
title_short Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol
title_sort nucleophilic arylation of halopurines facilitated by brønsted acid in fluoroalcohol
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865213/
https://www.ncbi.nlm.nih.gov/pubmed/31652675
http://dx.doi.org/10.3390/molecules24213812
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