Cargando…

Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol

Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and rea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Takenaga, Naoko, Shoji, Toshitaka, Menjo, Takayuki, Hirai, Akiko, Ueda, Shohei, Kikushima, Kotaro, Hanasaki, Tomonori, Dohi, Toshifumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865213/ https://www.ncbi.nlm.nih.gov/pubmed/31652675 http://dx.doi.org/10.3390/molecules24213812

Ejemplares similares

Enhanced Reactivity of [Hydroxy(tosyloxy)iodo]benzene in Fluoroalcohol Media. Efficient Direct Synthesis of Thienyl(aryl)iodonium Salts
por: Ito, Motoki, et al.
Publicado: (2010)

Nucleophilic Aromatic Substitution of Polyfluoroarene to Access Highly Functionalized 10-Phenylphenothiazine Derivatives
por: Kikushima, Kotaro, et al.
Publicado: (2021)

Taming Brønsted Acid Reactivity: Nucleophilic Substitutions of Propargylic Alcohols with N-Nucleophiles Mediated by Phosphorus-Based Brønsted Acid Catalysts
por: Radtanajiravong, Lalita, et al.
Publicado: (2019)

Recent progress in metal assisted multicomponent reactions in organic synthesis
por: Sakthivel, Kokila, et al.
Publicado: (2023)

Living/Controlled Anionic Polymerization of Glycolide in Fluoroalcohols: Toward Sustainable Bioplastics
por: Zhang, Pengfei, et al.
Publicado: (2023)

Nucleophilic arylation with tetraarylphosphonium salts
por: Deng, Zuyong, et al.
Publicado: (2016)

Synthesis of Uracil-Iodonium(III) Salts for Practical Utilization as Nucleobase Synthetic Modules
por: Takenaga, Naoko, et al.
Publicado: (2019)

Heteroaryliodonium(III) Salts as Highly Reactive Electrophiles
por: Takenaga, Naoko, et al.
Publicado: (2020)

Halogen-Induced Controllable Cyclizations as Diverse Heterocycle Synthetic Strategy
por: China, Hideyasu, et al.
Publicado: (2020)

Pd-Catalyzed Nucleophilic Fluorination of Aryl Bromides
por: Lee, Hong Geun, et al.
Publicado: (2014)

RAFT Polymerization of Styrene and Maleimide in the Presence of Fluoroalcohol: Hydrogen Bonding Effects with Classical Alternating Copolymerization as Reference
por: Yao, Fangjun, et al.
Publicado: (2017)

Autocatalytic Carbonyl Arylation through In Situ Release of Aryl Nucleophiles from N‐Aryl‐N′‐Silyldiazenes
por: Chauvier, Clément, et al.
Publicado: (2020)

Dataset on synthesis and crystallographic structure of phenyl(TMP)iodonium(III) acetate
por: China, Hideyasu, et al.
Publicado: (2019)

How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study
por: Campodónico, Paola R., et al.
Publicado: (2022)

Palladium-Catalyzed Organic Reactions Involving Hypervalent Iodine Reagents
por: Shetgaonkar, Samata E., et al.
Publicado: (2022)

Practical Synthesis of 2-Iodosobenzoic Acid (IBA) without Contamination by Hazardous 2-Iodoxybenzoic Acid (IBX) under Mild Conditions
por: China, Hideyasu, et al.
Publicado: (2021)

Tunable Gold‐catalyzed Reactions of Propargyl Alcohols and Aryl Nucleophiles
por: Jónsson, Helgi Freyr, et al.
Publicado: (2022)

Asymmetric synthesis of multifunctional aryl allyl ethers by nucleophilic catalysis
por: Zhao, Shuai, et al.
Publicado: (2019)

The 2‐Pyridyl Problem: Challenging Nucleophiles in Cross‐Coupling Arylations
por: Cook, Xinlan A. F., et al.
Publicado: (2020)

Challenging Metathesis Catalysts with Nucleophiles and Brønsted Base: Examining the Stability of State-of-the-Art Ruthenium Carbene Catalysts to Attack by Amines
por: Nascimento, Daniel L., et al.
Publicado: (2020)

Synthesis and Properties of Magnetic Aryl-Imidazolium Ionic Liquids with Dual Brønsted/Lewis Acidity
por: Chang, Jui-Cheng, et al.
Publicado: (2018)

Chiral Brønsted Acid‐Catalyzed Asymmetric Synthesis of N‐Aryl‐cis‐aziridine Carboxylate Esters
por: Bew, Sean P., et al.
Publicado: (2017)

Transition‐Metal‐Free Coupling of Polyfluorinated Arenes and Functionalized, Masked Aryl Nucleophiles
por: Finck, Lucie, et al.
Publicado: (2021)

Two-Chamber Aminocarbonylation of Aryl Bromides and Triflates Using Amino Acids as Nucleophiles
por: Lindman, Jens, et al.
Publicado: (2023)

Nucleophilic C4-selective (hetero) arylation of pyridines for facile synthesis of heterobiaryls
por: Kim, Kewon, et al.
Publicado: (2023)

Enantioselective Synthesis of α‐Aryl‐β(2)‐Amino‐Esters by Cooperative Isothiourea and Brønsted Acid Catalysis
por: Zhao, Feng, et al.
Publicado: (2021)

Non-Palladium-Catalyzed Oxidative Coupling Reactions Using Hypervalent Iodine Reagents
por: Shetgaonkar, Samata E., et al.
Publicado: (2022)

Stereospecific Pd-Catalyzed Cross-Coupling Reactions of Secondary Alkylboron Nucleophiles and Aryl Chlorides
por: Li, Ling, et al.
Publicado: (2014)

Ortho-selective C–H arylation of phenols with N-carboxyindoles under Brønsted acid- or Cu(i)-catalysis
por: Nguyen, Nguyen H., et al.
Publicado: (2021)

Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions
por: Babaev, Eugene V, et al.
Publicado: (2005)

Replacing Conventional Carbon Nucleophiles with Electrophiles: Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides
por: Everson, Daniel A., et al.
Publicado: (2012)

C(sp(3))-Arylation by Conformationally Accelerated Intramolecular Nucleophilic Aromatic Substitution (S(N)Ar)
por: Wales, Steven M., et al.
Publicado: (2022)

Three Component Cascade Reaction of Cyclohexanones, Aryl Amines, and Benzoylmethylene Malonates: Cooperative Enamine-Brønsted Acid Approach to Tetrahydroindoles
por: Cortes Vazquez, Jose, et al.
Publicado: (2022)

Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides
por: Markovic, Tim, et al.
Publicado: (2017)

Iron-Catalyzed Cross-Coupling of Bis-(aryl)manganese Nucleophiles with Alkenyl Halides: Optimization and Mechanistic Investigations
por: Rousseau, Lidie, et al.
Publicado: (2020)

Tunable Aryl Imidazolium Recyclable Ionic Liquid with Dual Brønsted–Lewis Acid as Green Catalyst for Friedel–Crafts Acylation and Thioesterification
por: Lin, Yi-Jyun, et al.
Publicado: (2020)

Asymmetric bronsted acid catalysis
por: Rueping, Magnus, et al.
Publicado: (2016)

Reactions of aryl dimethylphosphinothioate esters with anionic oxygen nucleophiles: transition state structure in 70% water–30% ethanol
por: Kalu, Georgina I., et al.
Publicado: (2021)

Nucleophilic Isocyanation
por: Yurino, Taiga, et al.
Publicado: (2020)

Brønsted acid catalysis of photosensitized cycloadditions
por: Sherbrook, Evan M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vchjbto118tcc3o5jrm8pk5b1e