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Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint
The restricted access of regulatory factors to their binding sites on DNA wrapped around the nucleosomes is generally interpreted in terms of molecular shielding exerted by nucleosomal structure and internucleosomal interactions. Binding of proteins to DNA often includes intercalation of hydrophobic...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867626/ https://www.ncbi.nlm.nih.gov/pubmed/31747397 http://dx.doi.org/10.1371/journal.pone.0224936 |