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Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation

HER2 is a transmembrane receptor tyrosine kinase, which plays a key role in breast cancer due to a common genomic amplification. It is used as a marker to stratify patients in the clinic and is targeted by a number of drugs including Trastuzumab and Lapatinib. HER2 has previously been shown to trans...

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Detalles Bibliográficos
Autores principales: Redmond, Aisling M., Omarjee, Soleilmane, Chernukhin, Igor, Le Romancer, Muriel, Carroll, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867699/
https://www.ncbi.nlm.nih.gov/pubmed/31747426
http://dx.doi.org/10.1371/journal.pone.0225180