Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury

mTORC1 is a protein kinase important for metabolism and is regulated by growth factor and nutrient signaling pathways, mediated by the Rheb and Rag GTPases, respectively. Here we provide the first animal model in which both pathways were upregulated through concurrent mutations in their GTPase-activ...

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Detalles Bibliográficos
Autores principales: Cho, Chun-Seok, Kowalsky, Allison H., Namkoong, Sim, Park, Sung-Rye, Wu, Shuangcheng, Kim, Boyoung, James, Amanda, Gu, Bondong, Semple, Ian A., Tohamy, Mohamed A., Solanki, Sumeet, Cho, Uhn-Soo, Greenson, Joel K., Shah, Yatrik M., Kim, Myungjin, Lee, Jun Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868011/
https://www.ncbi.nlm.nih.gov/pubmed/31754457
http://dx.doi.org/10.1038/s41421-019-0131-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868011/
https://www.ncbi.nlm.nih.gov/pubmed/31754457
http://dx.doi.org/10.1038/s41421-019-0131-9

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