Identification of cell context-dependent YAP-associated proteins reveals β(1) and β(4) integrin mediate YAP translocation independently of cell spreading

Yes-associated protein (YAP) is a transcriptional regulator and mechanotransducer, relaying extracellular matrix (ECM) stiffness into proliferative gene expression in 2D culture. Previous studies show that YAP activation is dependent on F-actin stress fiber mediated nuclear pore opening, however the...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Joanna Y., Dominguez, Antonia A., Nam, Sungmin, Stowers, Ryan S., Qi, Lei. S, Chaudhuri, Ovijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868278/
https://www.ncbi.nlm.nih.gov/pubmed/31748579
http://dx.doi.org/10.1038/s41598-019-53659-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868278/
https://www.ncbi.nlm.nih.gov/pubmed/31748579
http://dx.doi.org/10.1038/s41598-019-53659-4

Ejemplares similares