Cargando…

Direct interplay between stereochemistry and conformational preferences in aminoacylated oligoribonucleotides

To address the structural and dynamical consequences of amino-acid attachment at 2′- or 3′-hydroxyls of the terminal ribose in oligoribonucleotides, we have performed an extensive set of molecular dynamics simulations of model aminoacylated RNA trinucleotides. Our simulations suggest that 3′-modifie...

Descripción completa

Detalles Bibliográficos
Autores principales: Polyansky, Anton A, Kreuter, Mathias, Sutherland, John D, Zagrovic, Bojan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868383/
https://www.ncbi.nlm.nih.gov/pubmed/31612955
http://dx.doi.org/10.1093/nar/gkz902