HER3-targeted protein chimera forms endosomolytic capsomeres and self-assembles into stealth nucleocapsids for systemic tumor homing of RNA interference in vivo

RNA interference represents a potent intervention for cancer treatment but requires a robust delivery agent for transporting gene-modulating molecules, such as small interfering RNAs (siRNAs). Although numerous molecular approaches for siRNA delivery are adequate in vitro, delivery to therapeutic ta...

Descripción completa

Detalles Bibliográficos
Autores principales: Alonso-Valenteen, Felix, Pacheco, Sayuri, Srinivas, Dustin, Rentsendorj, Altan, Chu, David, Lubow, Jay, Sims, Jessica, Miao, Tianxin, Mikhael, Simoun, Hwang, Jae Youn, Abrol, Ravinder, Medina Kauwe, Lali K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868389/
https://www.ncbi.nlm.nih.gov/pubmed/31617560
http://dx.doi.org/10.1093/nar/gkz900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868389/
https://www.ncbi.nlm.nih.gov/pubmed/31617560
http://dx.doi.org/10.1093/nar/gkz900

Ejemplares similares