Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing

Although group II intron ribozymes are intensively studied the question how structural dynamics affects splicing catalysis has remained elusive. We report for the first time that the group II intron domain 6 exists in a secondary structure equilibrium between a single- and a two-nucleotide bulge con...

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Detalles Bibliográficos
Autores principales: Plangger, Raphael, Juen, Michael Andreas, Hoernes, Thomas Philipp, Nußbaumer, Felix, Kremser, Johannes, Strebitzer, Elisabeth, Klingler, David, Erharter, Kevin, Tollinger, Martin, Erlacher, Matthias David, Kreutz, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868427/
https://www.ncbi.nlm.nih.gov/pubmed/31665419
http://dx.doi.org/10.1093/nar/gkz965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868427/
https://www.ncbi.nlm.nih.gov/pubmed/31665419
http://dx.doi.org/10.1093/nar/gkz965

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