Impact of water hardness on oxytetracycline oral bioavailability in fed and fasted piglets

Water hardness is a critical factor that affects oxytetracycline dissolution by chelation with cations. These interactions may lead to impaired dosing and consequently decrease absorption. Moreover, feed present in gastrointestinal tract may interact with antibiotic and alter pharmacokinetic paramet...

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Detalles Bibliográficos
Autores principales: Decundo, Julieta M., Diéguez, Susana N., Martínez, Guadalupe, Romanelli, Agustina, Fernández Paggi, María B., Pérez Gaudio, Denisa S., Amanto, Fabián A., Soraci, Alejandro L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868454/
https://www.ncbi.nlm.nih.gov/pubmed/31282118
http://dx.doi.org/10.1002/vms3.185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868454/
https://www.ncbi.nlm.nih.gov/pubmed/31282118
http://dx.doi.org/10.1002/vms3.185

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