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Impact of water hardness on oxytetracycline oral bioavailability in fed and fasted piglets
Water hardness is a critical factor that affects oxytetracycline dissolution by chelation with cations. These interactions may lead to impaired dosing and consequently decrease absorption. Moreover, feed present in gastrointestinal tract may interact with antibiotic and alter pharmacokinetic paramet...
Autores principales: | Decundo, Julieta M., Diéguez, Susana N., Martínez, Guadalupe, Romanelli, Agustina, Fernández Paggi, María B., Pérez Gaudio, Denisa S., Amanto, Fabián A., Soraci, Alejandro L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868454/ https://www.ncbi.nlm.nih.gov/pubmed/31282118 http://dx.doi.org/10.1002/vms3.185 |
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