Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell–Derived Insulin-Expressing Cells Require NEUROD1

Inactivation of the β-cell transcription factor NEUROD1 causes diabetes in mice and humans. In this study, we uncovered novel functions of NEUROD1 during murine islet cell development and during the differentiation of human embryonic stem cells (HESCs) into insulin-producing cells. In mice, we deter...

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Detalles Bibliográficos
Autores principales: Romer, Anthony I., Singer, Ruth A., Sui, Lina, Egli, Dieter, Sussel, Lori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2019
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868472/
https://www.ncbi.nlm.nih.gov/pubmed/31519700
http://dx.doi.org/10.2337/db19-0117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868472/
https://www.ncbi.nlm.nih.gov/pubmed/31519700
http://dx.doi.org/10.2337/db19-0117

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