R-Loops Promote Antisense Transcription across the Mammalian Genome

Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding genes in mammals and emanate from gene promoter, enhancer, and termination regions. However, their origin and biological purpose remain unclear. We show that these antisense lncRNA can be generated by R-loops that form...

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Detalles Bibliográficos
Autores principales: Tan-Wong, Sue Mei, Dhir, Somdutta, Proudfoot, Nick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868509/
https://www.ncbi.nlm.nih.gov/pubmed/31679819
http://dx.doi.org/10.1016/j.molcel.2019.10.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868509/
https://www.ncbi.nlm.nih.gov/pubmed/31679819
http://dx.doi.org/10.1016/j.molcel.2019.10.002

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